NPB Neurobiology, Physiology & Behavior

James S. Trimmer
James S. Trimmer
Professor
175 Briggs Hall
Office: 530.754.6075
Lab: 530.754.6076

Fax: 530.754.6079
jtrimmer (at) ucdavis (dot) edu

Degrees:
BS., University of California, San Diego, 1981
PhD., University of California, San Diego, Marine Biology, 1987

Awards:
American Heart Association Established Investigator Award, 1994-1999
Jacob Javits Neuroscience Investigator (MERIT) Award, National Institute of Neurological Diseases and Stroke, National Institutes of Health, 2000-2007


Department and Center Affiliations:
Center for Neuroscience Department of Physiology and Membrane Biology (School of Medicine)

Professional Societies:
Society for Neuroscience

American Society for Cell Biology

Biophysical Society


Grad Group Affiliations:
Neuroscience
Biochemistry and Molecular Biology
Cell and Developmental Biology

Publications (since 2005):
Strassle, B. W., Menegola, M., Rhodes, K. J.,  and J. S. Trimmer. (2005).  Light and Electron Microscopic Analysis of KChIP and Kv4 Localization in Rat Cerebellar Granule Cells. J. Comp. Neurol. 484:144-155.

Van Wart, A., Boiko, T., Trimmer, J. S., and G. Matthews. (2005).  Novel Clustering of Sodium Channel Nav1.1 with Ankyrin-G and Neurofascin at Discrete Sites in the Inner Plexiform Layer of the Retina. Mol. Cell. Neurosci. 28:661-673.

Misonou, H. Mohapatra, D. P., and J. S. Trimmer. (2005).  Kv2.1: A Voltage-gated K+ Channel Critical to Dynamic Control of Neuronal Excitability. Neurotoxicology 26:743-752.

Meyer, M. P., Trimmer, J. S., Gilthorpe, J. D., and S. J. Smith. (2005).  Characterization of Zebrafish PSD-95 Gene Family Members. J. Neurobiol. 63:91-105.

Misonou, H., and J. S. Trimmer. (2005).  A Primary Culture System for Biochemical Analyses of Neuronal Proteins. J. Neurosci. Methods 144:165-173.

Misonou, H., Menegola, M., Mohapatra, D. P., and J. S. Trimmer.  (2005). Calcium- and Metabolic-State Dependent Modulation of the Voltage-Dependent Kv2.1 Channel Regulates Neuronal Excitability in Response to Ischemia. J. Neurosci. 25:11184-11193.

Mohapatra, D. P., and J. S. Trimmer.  (2006). The Kv2.1 C-Terminus Can Autonomously Transfer Kv2.1-Like Phosphorylation-Dependent Localization, Voltage-Dependent Gating and Muscarinic Modulation to Diverse Kv Channels. J. Neurosci. 26:685-695.

Misonou, H., Menegola, M., Buchwalder, L., Park, E. W., Meredith, A., Rhodes, K. J., Aldrich, R. W., and J. S. Trimmer.  (2006).  Immunolocalization of the Ca2+-activated K+ Channel Slo1 in Axons and Nerve Terminals of Mammalian Brain and Cultured Neurons. J. Comp. Neurol. 496:289-302.

Rasband, M. N., and J. S. Trimmer. (2006). Voltage-gated Potassium Channels in Sensory Neurons (Chapter 11, pp. 323-352).  In The Nociceptive Membrane (U. Oh, ed.)  Academic Press, San Diego

*Park, K.-S., *Mohapatra, D. P., Misonou, H., and J. S. Trimmer. (2006). Graded Regulation of the Kv2.1 Potassium Channel by Variable Phosphorylation. Science 313:976-979.  *These authors contributed equally to this work.  Faculty of 1000 Biology: http://www.f1000biology.com/article/id/1040693/evaluation.

Rhodes, K. J., and J. S. Trimmer. (2006).  Antibodies as Valuable Neuroscience Research Tools versus Reagents of Mass Distraction. J. Neurosci. 26:8017-8020.

Menegola, M., and J. S. Trimmer. (2006). Unanticipated Region- and Cell-specific Downregulation of Individual KChIP Auxiliary Subunit Isotypes in Kv4.2 Knockout Mouse Brain. J. Neurosci. 26:12137-12142.

Clark E., Vacher H, and J. S. Trimmer. (2006). Kv1.1 takes a deTOR from the Axon to the Dendrite. Neuron 52:399-401.

Vacher, H., Misonou, H., and J. S. Trimmer. (2006). Determinants of Voltage-Gated Potassium Channel Distribution in Mammalian Neurons. (Chapter 12, pp. 244-270. In Protein Trafficking in Neurons (A. J. Bean, ed) Elsevier Academic Press, London.

Misonou, H., Menegola, M., Mohapatra, D. P., Guy, L. K., Park, K.-S.,and J. S. Trimmer. (2006). Bidirectional Activity-Dependent Regulation of Neuronal Ion Channel Phosphorylation. J. Neurosci. 26:13505-13514. Chosen as the highlighted paper of the “Cellular/Molecular section of "This Week in The Journal" for the Dec 27 issue of the Journal of Neuroscience.

Van Wart, A., Trimmer, J. S., and G. Matthews. (2007). Polarized Distribution of Ion Channels Within Microdomains of the Axon Initial Segment. J. Comp. Neurol. 500:339-352.

Vacher, H., Mohapatra, D. P., Misonou, H, and J. S. Trimmer. (2007). Regulation of Kv1 Channel Trafficking by the Mamba Snake Neurotoxin Dendrotoxin K. FASEB J. 21:906-914. Faculty of 1000 Biology: http://www.f1000biology.com/article/id/1058723/evaluation

Rasmussen, H. B., Frøkjær-Jensen, C., Jensen, C. S., Jensen, H. S., Jørgensen, N. K., Misonou, H., Trimmer, J. S., Olesen, S.-P., and N. Schmitt. (2007). Requirement of Subunit Co-Assembly and Ankyrin-G for M Channel Localization at the Axon Initial Segment. J. Cell Sci. 120:953-963.

Mohapatra, D. P., Vacher, H., and J. S. Trimmer. (2007). The Surprising Catch of a Voltage-Gated Potassium Channel in a Neuronal SNARE. Science STKE: pe37.

Park, K.-S., Mohapatra, D. P., and J. S. Trimmer. (2007). Proteomic Analyses of Kv2.1 Channel Phosphorylation Sites Determining Cell Background-Specific Differences in Function. Channels 1: 59-61.

Yang, J.-W., Vacher, H., Park, K.-S., Clark, E, and J. S. Trimmer. (2007). Trafficking-dependent Phosphorylation of Kv1.2 Regulates Voltage-gated Potassium Channel Cell Surface Expression. Proc. Nat. Acad. Sci. USA 104: 20055-20060. http://www.pnas.org/cgi/doi/10.1073/pnas.0708574104

Park, K. S., Yang, J. W., Seikel, E., and J. S. Trimmer (2008).  Potassium Channel Phosphorylation in Excitable Cells: Providing Dynamic Functional Variability to a Diverse Family of Ion Channels. Physiology 23:49-57.

Mohapatra, D. P., Siino, D. F., and J. S. Trimmer. (2008). Interdomain Cytoplasmic Interactions Govern the Intracellular Trafficking, Gating and Modulation of the Kv2.1 Channel. J. Neurosci. 28: 4982-4994.

Research Interests:
We are interested in how neurons regulate electrical excitability through effects on ion channel expression, localizatio and function, and how these are dynamically modulated in development and disease, and in response to neuromodulation and activity.

Laboratory Personnel:
Trimmer laboratory / 231 Briggs Hall - Helene Vacher (postdoc), Frank Bernedt (postdoc), Moon Young Kim (postdoc), Ed Seikel (BMB graduate student), Kate McKiernan (junior specialist), Masayo Morishita (Assistant Project Scientist), David Tran (Undergraduate student assistant), Lisa Ha (Undergraduate student assistant), Emmanuel Njoku (Undergraduate student assistant)
Teaching Interests:
Cellular Neuroscience, Cell Signaling

Courses Taught:
NSC 221 Cellular Neuroscience - Term(s): Fall