NPB Neurobiology, Physiology & Behavior

College of Biological Sciences - UC Davis
Home | Undergraduates | Directory | Seminars | Graduate Programs | Downloads
Calendars | Related Links | New Faculty Positions | About NPB | Health & Safety

Aldrin V. Gomes
Assistant Professor
177 Briggs Hall
530.754-9548
avgomes (at) ucdavis (dot) edu
Degrees:
B.S., University of the West Indies, Trinidad, 1991
PhD., University of the West Indies, Trinidad, 1998

Awards:
American Heart Association Travel Award, 2004
American Society Biochemistry and Molecular Biology Travel Fellowship, 2000
Biochemical Society Travel Fellowship, 2000
International Union of Biochemistry and Molecular Biology Young Scientist Award, 1997
University of the West Indies School of Medicine Alpha Omega Merit Award, 1995

Research Interests:
My research interests focus on determining the importance of the ubiquitin-proteasome system in cardioprotective signaling. The ubiquitin-proteasome system is the primary mechanism of protein degradation in all cells. Functional proteomics is being utilized to investigate the proteasome complex in the normal, protected, and diseased heart.
Selected Publications:
Drews, O., Wildgruber, R., Zong, C., Sukop, U., Nissum, M., Gomes, A.V., Ping, P. (2007) Mammalian proteasome subpopulations with distinct molecular compositions and proteolytic activities. Molecular and Cellular Proteomics. In press.

Lounes, K.C., Demeler, B., Anderson, D.E., Gomes, A.V., Potter, J.D., Nassar, R., Anderson, P.A.W. (2007) Cardiac Troponin T Forms a Tetramer In Vitro. Biochemistry in press.

Gomes, A.V., Zong, C., Edmondson, R., Li, X., Stefani, E., Zhang, J., Jones, R.C., Thyparambil, S., Wang, G.W., Qiao, X., Bardag-Gorce, F., Ping, P. (2006) Mapping the Murine Cardiac 26S Proteasome Complexes. Circulation Research 99:362-71.

Zong, C., Gomes, A.V., Drews, O., Li, X., Young, G.W., Berhane, B., Qiao, X., French, S.W., Bardag-Gorce, F., Ping, P. (2006) Regulation of Murine Cardiac 20S Proteasomes: Role of Associating Partners. Circulation Research 99:372-80.

Gomes, A.V., Zong, C., Ping, P. (2006) Protein Degradation by the 26S Proteasome System in the Normal and Stressed Myocardium. Antioxidants & Redox Signaling 9/10:1677-1691.

Ross E. M., Mateu, D., Gomes, A.V., Arana, A., Tran, T., Litosch, I. (2006) Structural Determinants for Phosphatidic Acid Regulation of Phospholipase C-ß1. J. Biol. Chem. 281:33087-94.

Gomes, A.V., Liang, J.S., Potter, J.D. (2005) Mutations in Human Cardiac Troponin I that is associated with Restrictive Cardiomyopathy affect basal ATPase Activity and Calcium Sensitivity of Force Development. J. Biol. Chem. 280:30909-15.

Gomes, A.V., Harada, K. and Potter, J.D. (2005) Effect of the N-terminal Familial Hypertrophic Cardiomyopathy causing Mutation, R21C, on the Physiological Function of Human Cardiac Troponin I. J. Molecular and Cellular Cardiology 39:754-765.

Venkatraman, G., Gomes, A.V., Kerrick, G.W., Potter, J.D. (2005) Characterization of Troponin T Dilated Cardiomyopathy Mutations in the Fetal Troponin. J. Biol. Chem. 280, 17584-92.

Gomes, A.V., Zong, C., Edmondson, R., Berhane, B., Wang, G.W., Qiao, X., Vondriska, T., Zhang, J., Whitelegge, J., Jones, J., Joshua, I.,
Thyparambil, S., Young, G., Le, S., Pantaleon, D., Loo, J., Ping, P. (2005) The Murine Cardiac 26S Proteasome: An Organelle Awaits Exploration. Ann. New York Acad. Sci. 1047:197-207.

Gomes, A.V., Venkatraman, G., and Potter, J.D. (2005). The Miscommunicative Cardiac Cell: when good Proteins go bad. Ann. New York Acad. Sci. 1047:30-37.

Gomes, A.V., Venkatraman, G., Davis, J.P., Tikunova, S.B., Engel, P., Solaro, R.J., and Potter, J.D. (2004) Cardiac Troponin T Isoforms affect the Ca2+ Sensitivity of Force Development in the presence of Slow Skeletal Troponin I: Insights into the Role of Troponin T isoforms in the Fetal Heart. J. Biol. Chem. 279, 49579-87.

Everhart, D., Cartier, G.E., Malhotra, A. Gomes, A.V., McIntosh, J.M., and Luetje, C.W. (2004) Determinants of potency on a-conotoxin-MII, a peptide antagonist of neuronal nicotinic receptors. Biochemistry 43, 2732-2737.

Gutierrez-Ford, C., Levay, C., Gomes, A.V., Perera, E.M., Benovic, J.L., Berkovitz, G.D. and Slepak, V.Z. (2003) Tescalcin, a Novel Calcium-binding Protein with a single EF-Hand: Metal-binding properties, localization in tissues and cells, and effect on calcinuerin. Biochemistry 42, 14553-14565.

Venkatraman, G., Harada K., Gomes, A.V., Kerrick, W. G., Potter, J.D. (2003) Different functional properties of two troponin T mutants that cause Dilated Cardiomyopathy. J. Biol. Chem. 278, 41670-41676.

Gomes, A.V., Guzman, G., Zhao, J., and Potter, J.D. (2002) Cardiac Troponin T Isoforms Affect the Calcium Sensitivity and Inhibition of Force Development. Insights into the Role of Troponin T Isoforms in the Heart. J. Biol. Chem. 277, 35341-35349.

Lang, R., Gomes, A.V., Zhao, J., Housmans, P.R., Miller, T., and Potter, J.D. (2002) Functional Analysis of a Troponin I (R145G) Mutation Associated with Familial Hypertrophic Cardiomyopathy. J. Biol. Chem. 277, 11670-11678.