NPB Neurobiology, Physiology & Behavior

College of Biological Sciences - UC Davis
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Ernest S. Chang
Professor
Bodega Marine Laboratory
P.O. Box 247
Bodega Bay, CA 94923
707.875.2061
eschang (at) ucdavis (dot) edu
Degrees:
B.A., Zoology, University of California, Berkeley, 1973
Ph.D., Biology, University of California, Los Angeles, 1978
Teaching Interests:
Comparative endocrinology; marine physiological ecology
Research Interests:
Chemical mediation of the growth, development, and reproduction of marine invertebrates. Use of molecular techniques to examine hormone action at the cellular level.
Selected Publications:
Kao, H.-w., and E. S. Chang.  1999.  Transformation of crab limbs by interspecies transplantation of limb tissues.  Invert. Reprod. Develop. 35:155-165.

Chang, E. S., S. A. Chang, R. Keller, P. S. Reddy, M. J. Snyder, and J. L. Spees.  1999.  Quantification of stress in lobsters: Crustacean hyperglycemic hormone, stress proteins, and gene expression.  Amer. Zool. 39:487-495.

Chang, E. S., S. A. Chang, B. S. Beltz, and E. A. Kravitz.  1999.  Crustacean hyperglycemic hormone in the lobster central nervous system: Localization and release from cells in the subesophageal ganglion and thoracic second roots.  J. Comp. Neurol. 414:50-56.

LeBlanc, G. A., P. M. Campbell, P. den Besten, R. P. Brown, E. S. Chang, J. R. Coats, P. L. deFur, T. Dhadialla, J. Edwards, L. M. Riddiford, M. G. Simpson, T. W. Snell, M. Thorndyke, and F. Matsumura.  1999.  The endocrinology of invertebrates.  In “Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment” (P. L. deFur, M. Crane, C. Ingersoll, and L. Tattersfield, eds.), pp. 23-106.  SETAC Press, Pensacola, FL.

Peeke, H. V. S., G. Blank, M. H. Figler, and E. S. Chang.  2000.  Effects of exogenous serotonin on substrate seeking and shelter competition in juvenile lobsters (Homarus americanus).  J. Comp. Physiol. A 186:575-582.

Stentiford, G. D., E. S. Chang, S. A. Chang, and D. M. Neil.  2001.  Carbohydrate dynamics and the crustacean hyperglycaemic hormone (CHH): Effects of parasitic infection in lobsters.  Gen Comp. Endocrinol. 121:13-22.

Absher, M. D., H. V. S. Peeke, E. S. Chang, and M. J. Snyder.  2001.  Intraspecific competition and aggression for shells in the hermit crab, Pagurus samuelis.  Mar. Freshwater Behav. Physiol. 34:117-123.

Chang, E. S.  2001.  Crustacean hyperglycemic hormone family: Old paradigms and new perspectives.  Amer. Zool. 41:380-388.

Okazaki, R. K., W. Ye, N. J. Berthelemy-Okazaki, and E. S. Chang.  2001.  Preliminary study of heat shock proteins in nemerteans.  Hydrobiologia 456:211-219.

Chang, E. S., S. A. Chang, and E. P. Mulder.  2001.  Hormones in the lives of crustaceans: An overview.  Amer. Zool. 41:1090-1097.

Spees, J. L., S. A. Chang, M. J. Snyder, and E. S. Chang.  2002.  Thermal acclimation and stress in the American lobster, Homarus americanus: Equivalent temperature shifts elicit unique gene expression patterns for molecular chaperones and polyubiquitin.  Cell Stress Chaperones 7:97-106.

Koenders, A., X. Yu, E. S. Chang, and D. L. Mykles.  2002.  Ubiquitin and actin expression in claw muscles of land crab, Gecarcinus lateralis, and American lobster, Homarus americanus: Differential expression of ubiquitin in two slow muscle fiber types during molt-induced atrophy.  J. Exp. Zool. 292:618-632.

Yu, X., E. S. Chang, and D. L. Mykles.  2002.  Characterization of limb autotomy factor - proecdysis (LAFPRO), isolated from limb regenerates, that suspends molting in the land crab, Gecarcinus lateralis.  Biol. Bull. 202:204-212.

Spees, J. L., S. A. Chang, M. J. Snyder, and E. S. Chang.  2002.  Osmotic induction of stress-responsive gene expression in the American lobster, Homarus americanus.  Biol. Bull. 203:331-337.

Spees, J. L., S. A. Chang, D. L. Mykles, M. J. Snyder, and E. S. Chang.  2003.  Molt cycle-dependent molecular chaperone and polyubiquitin gene expression in lobster.  Cell Stress Chaperones 8:258-264.

Figler, M. H., H. V. S. Peeke, M. J. Snyder and E. S. Chang.  2004.  Effect of egg removal on maternal aggression, biogenic amines, and stress indicators in ovigerous lobsters (Homarus americanus).  Mar. Freshw. Behav. Physiol. 37:43-54.

Chang, E. S., and W. R. Kaufman.  2005.  Endocrinology of Crustacea and Chelicerata.  In “Comprehensive Molecular Insect Science” (L. I. Gilbert, K. Iatrou, and S. S. Gill, eds.), vol. 3, pp. 805-842.  Elsevier B.V., Oxford. 

Chang, E. S. 2005. Stressed-out lobsters: Crustacean hyperglycemic hormone and stress proteins. Integrat. Comp. Biol. 45:43-50.

Chang, E. S., Stentiford, G. D., Neil, D. M., and Chang, S. A.  2005.  Crustacean hyperglycemic hormone and hemolymph metabolites: Stress responses in two lobster species.  In “Aquaculture and Pathobiology of Crustacean and Other Species.  Proceedings of the 32nd U.S.-Japan Meeting on Aquaculture” (Y. Sakai, J. P. McVey, D. Jang, E. McVey, and M. Caesar, eds.),  pp. 77-85.  UJNR Technical Report 32.  NOAA, Silver Spring, MD.

Smith, S. G., and Chang, E. S.  2007.  Molting and growth.  In “The Blue Crab, Callinectes sapidus” (V. S. Kennedy and L. E. Cronin, eds.), pp. 197-254.  Maryland Sea Grant, Baltimore, MD.

Kim, H.-W., Chang, E. S., and Mykles, D. L.  2005.  Three calpains and ecdysone receptor in the land crab, Gecarcinus lateralis: Sequences, expression, and effects of elevated ecdysteroid induced by eyestalk ablation.  J. Exp. Biol. 208:3177-3197.

De Guise, S., Maratea, J., Chang, E. S., and Perkins, C.  2005. Resmethrin immunotoxicity and endocrine disrupting effects in the American lobster (Homarus americanus) upon experimental exposure.  J. Shellfish Res. 24:781-786.

Walker, A. N., Bush, P., Wilson, T., Chang, E. S., Miller, T., and Horst, M. N.  2005.  Metabolic effects of acute exposure to methoprene in the American lobster, Homarus americanus.  J. Shellfish Res. 24:787-794.

Medler, S., Brown, K. J., Chang, E. S., and Mykles, D. L.  2005.  Eyestalk ablation has little effect on actin and myosin heavy chain gene expression in adult lobster skeletal muscles.  Biol. Bull.  208:127-137.

Walker, A. N., Bush, P., Puritz, J., Wilson, T., Chang, E. S., Miller, T., Holloway, K., and Horst, M. N.  2005.  Bioaccumulation and metabolic effects of the endocrine disruptor methoprene in the lobster, Homarus americanus.  Integrat. Comp. Biol. 45:118-126.

Ridgway, I. D., Taylor, A. C., Atkinson, R. J. A., Stentiford, G. D., Chang, S. A., Chang, E. S., and Neil, D. M..  2006. Morbidity and mortality in Norway lobster, Nephrops norvegicus: Physiological, immunological and pathological effects of aerial exposure.  J. Exp. Mar. Biol. Ecol.  328:251-264.

Roepke, T. A., Chang, E. S. and Cherr, G. N.  2006.  Maternal exposure to estradiol and endocrine disrupting compounds alters the sensitivity of sea urchin embryos and the expression of an orphan steroid receptor.  J. Exp. Zool. 305A:830-841.

Ridgway, I., Taylor, A. C., Atkinson, R. J. A., Chang, E. S., and Neil, D. M.  2006.  Impact of capture method and trawl duration on the health status of the Norway lobster, Nephrops norvegicus.  J. Exp. Mar. Biol. Ecol. 339:135-147.

Lee, K. J., Kim, H.-W., Doran, R. M., Gomez, A. M., Chang, E. S., Covi, J. A., and Mykles, D. L.  2007.  Molt-inhibiting hormone from the tropical land crab, Gecarcinus lateralis: Cloning, tissue expression, and expression of biologically active recombinant peptide in yeast.  Gen. Comp. Endocrinol.  150:505-513.

Horst, M. N., Walker, A. N., Bush, P., Wilson, T., Chang, E. S., Miller, T., and Larkin, P.  2007.  Pesticide induced alterations in gene expression in the lobster, Homarus americanus.  Comp. Biochem. Physiol. D 2:44-52.

Medler, S., Lilley, T., Riehl, J. H., Mulder, E. P., Chang, E. S., and Mykles, D. L. 2007. Myofibrillar gene expression in diffentiating lobster claw muscle. J. Exp. Zool. 307A:281-295.

Lee, S. G., Bader, B. D, Chang, E. S., and Mykles, D. L. 2007. Effects of elevated ecdysteroid on tissue expression of three guanylyl cyclases in the tropical land crab, Gecarcinus lateralis: possible roles of neuropeptide signaling in the molting gland. J. Exp. Biol. 210:3245-3254.

Shechter, A., Tom, M., Yudkovski Y., Weil, S., Chang, S. A., Chang, E. S. Chalifa-Caspi,V., Berman, A., and Sagi, A. 2007.  Search for hepatopancreatic ecdysteroid-responsive genes during the crayfish molt cycle: from a single gene to multigenicity.  J. Exp. Biol. 210:3525-3537.

Medler, S., Chang, E. S., and Mykles, D. L. 2007. Muscle-specific calpain is restricted to regions near motor endplates in differentiating lobster claw muscles. Comp. Biochem. Physiol. A 148:591-598.

Chang, E. S., and Sagi, A.  2008.  Male reproductive hormones.  In: “Reproductive Biology of Crustaceans: Case Studies of Decapod Crustaceans” (E. Mente, ed.), pp. 299-317.  Science Publishers, Enfield, NH.

Zarubin, T. P., Chang, E. S., and Mykles, D. L.  2008.  Expression of recombinant eyestalk crustacean hyperglycemic hormone from the tropical land crab, Gecarcinus lateralis: Effects on hemolymph glucose and Y-organ ecdysteroidogenesis.  Molec. Biol. Rep.  In press.

Chang, E. S.  2008.  The crustacean endocrine system and pleiotropic chemical messengers.  In: “Chemical Communication in Crustaceans” (T. Breithaup and M. Thiel, eds.).  Springer, New York, NY.  In press.